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NU/J The two main defects of mice homozygous for the nude spontaneous mutation (Foxn1 nu, formerly Hfh11 nu) are abnormal hair growth and defective development of the thymic epithelium. Nude mice are also athymic; homozygous nude mice lack T cells and suffer from a lack of cell-mediated immunity.

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What nude mouse strains exist, and how do they differ? In , The Jackson Laboratory (JAX) imported the Foxn1nu mutation from the National Institutes of Health (NIH) on an outbred stock of mice. Today, JAX now maintains several nude strains from NIH. Here’s some information on the strains most often used by researchers.

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